Journal articles

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Plasma gelsolin in patients

Dahl B, Schiødt FV, Ott P, Gvozdenovic R, Yin HL, Lee WM: Plasma gelsolin is reduced in trauma patients. Shock 1999; 12: 102-104.

DiNubile MJ, Stossel TP, Ljunghusen OC, Ferrara JF, Antin JH: Prognostic implications of declining plasma gelsolin levels after allogeneic stem cell transplantation. Blood 2002; 100: 4367-4371.

DiNubile MJ: Plasma gelsolin: in search of its raison d’etre. Focus on “modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin”. Editorial. Am J Physiol Cell Physiol 2007; 292: 1240-1242.

Lee P-S, Drager L, Stossel TP, Moore FD Jr., Rogers SO: Relationship of plasma gelsolin levels to outcomes in critically ill surgical patients. Ann Surg 2006; 243: 399–403.

Lee P-S, Patel SR, Christiani DC, Bajwa E, Stossel TP, Waxman AB: Plasma gelsolin depletion and circulating actin in sepsis: A Pilot Study. PLoS ONE 2008; 3: e3712.

Lee P-S, Sampath K, Karumanchi SA, Tamez H, Bhan I, Isakova T, Gutierrez OM, Wolf M, Chang Y, Stossel TP, Thadhani R: Plasma gelsolin, circulating actin, and chronic hemodialysis mortality. J Am Soc Nephrology 2009; accepted manuscript.

Lind SE, Smith DB, Janmey PA, Stossel TP: Depression of gelsolin levels and detection of gelsolin-actin complexes in plasma of patients with acute lung injury. Am Rev Resp Dis 1988; 138: 429-434.

Mounzer KC, Moncure M, Smith YR, DiNubile MJ: Relationship of admission plasma gelsolin levels to clinical outcomes in patients after major trauma. Am J Respir Crit Care Med 1999; 160: 1673-1681.

Osborn TM, Verdrengh M, Stossel TP, Tarkowsk A, Bokarewa M: Decreased levels of the gelsolin plasma isoform in patients with rheumatoid arthritis. Arthritis Res Ther 2008; 10: R117.

Smith DB, Janmey PA, Sherwood JA, Howard RJ, Lind SE: Decreased plasma gelsolin levels in patients with Plasmodium falciparum: A consequence of hemolysis? Blood 1988; 72: 214-218.

Suhler E, Lin W, Yin HL, Lee WM: Decreased plasma gelsolin concentrations in acute liver failure, myocardial infarction, septic shock, and myonecrosis. Crit Care Med 1997; 25: 594-598.

Wang HH, Cheng BL, Chen QX, Wu SJ, Chen L, Xie GH, Jin Y, Fang XM: Time course of plasma gelsolin concentrations during severe sepsis in critically ill surgical patients. Crit Care Med 2008; 12: R106.

Gelsolin and plasma gelsolin biochemistry and actions

Ashish, Paine MS, Perryman PB, Yang L, Yin HL, Krueger JK: Global structure changes associated with Ca2+ activation of full-length human plasma gelsolin. J Biol Chem 2007; 282: 25884-25892.

Bucki R, Georges PC, Espinassous Q, Funaki M, Pastore JJ, Chaby R, Janmey PA: Inactivation of endotoxin by human plasma gelsolin. Biochem 2005;44: 9590-9597.

Bucki R, Byfield FJ, Kulakowska A, McCormick ME, Drozdowski W, Namiot Z, Hartung T, Janmey PA: Extracellular gelsolin binds lipoteichoic acid and modulates cellular response to proinflammatory bacterial wall components. J Immunol 2008; 181: 4936-4944.

Chauhan VP, Ray I, Chauhan A, Wisniewski HM: Binding of gelsolin, a secretory protein, to amyloid beta-protein. Biochem Biophys Res Commun 1999; 258: 241-246.

Goetzl EJ, Lee H, Azuma T, Stossel TP, Turck CW, Karliner JS: Gelsolin binding and cellular presentation of lysophosphatidic acid. J Bio Chem 2000; 275:14573-14578.

Kater A, Henke MO, Rubin BK: The role of DNA and actin polymers on the polymer structure and rheology of cystic fibrosis sputum and deploymerization by gelsolin or thymosin beta 4. Ann NY Acad Sci 2007; 1112: 140-153.

Lee WM, Galbraith RM: The extra cellular actin-scavenger system and actin toxicity. N Engl J Med 1992; 326: 1335-1341.

Mintzer M, Sargsyan H, Bittman R: Lysophosphatidic acid and lipopolysaccharide bind to the PIP2-binding domain of gelsolin. Biochimica et Biophysica Acta 2006; 1758: 85-89.

Osborn T, Dahlgren C, Hartwig JH, Stossel TP: Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. Am J Physiol Cell Physiol 2007; 292: C1323-1330.

Vasconcellos CA, Allen PG, Wohl ME, Drazen JM, Janmey PA, Stossel TP: Reduction in viscosity of cystic fibrosis sputum in vitro by gelsolin. Science 1994; 263: 969-971.

Wen D, Corina K, Chow EP, Miller S, Janmey PA, Pepinsky RB: The plasma and cytoplasmic forms of human gelsolin differ in disulfide structure. Biochemistry 1996; 35: 9700-9709.

Gelsolin in animal studies

Becker PM, Kazi AA, Wadgaonkar R, Pearse DB, Kwiatkowski DJ, Garcia JG: Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice. Am J Resp Cell Mol Biol 2003; 28: 478-484.

Chavko M, Prusaczyk WK, McCarron RM: Lung injury and recovery after exposure to blast overpressure. J Trauma 2006; 61: 933-942.

Christofidou-Solomidou M, Scherpereel A, Solomides CC, Muzykantov VR, Machtay M, Albelda SM, DiNubile MJ: Changes in plasma gelsolin concentration during acute oxidant lung injury in mice. Lung 2002; 180: 91-104.

Christofidou-Solomidou M, Scherperrel A, Solomides CC, Christie JD, Stossel TP, DiNubile MJ: Recombinant plasma gelsolin diminishes the acute inflammatory response to hyperoxia in mice. J Invest Med 2002; 50: 54-60.

Hirko AC, Meyer EM, King MA, Hughes JA. Peripheral transgene expression of plasma gelsolin reduces amyloid in transgenic mouse models of Alzheimer’s disease. Mol Therapy 2007; 15: 1623-1629.

Jordan JR, Moore EE, Damle SS, Eckels P, Johnson JL, Roach JP, Redzic JS, Hansen KC, Banerjee A: Gelsolin is depleted in post-shock mesenteric lymph. J Surg Res 2007; 143: 130–135.

Lee P-S, Waxman AB, Cotich KL, Chung SW, Perrella MA, Stossel TP: Plasma gelsolin is a marker and therapeutic agent in animal sepsis. Crit Care Med 2007; 35: 849–855.

Matsuoka Y, Saito M, LaFrancois J, Saito M, Gaynor K, Olm V, Wang L, Casey E, Lu Y, Shiratori C, Lemere C, Duff K: Novel therapeutic approach for the treatment of Alzheimer’s disease by peripheral administration of agents with an affinity to β-amyloid. J Neuroscience 2003; 23: 29-33.

Rothenbach PA, Dahl B, Schwartz JJ, O’Keefe GE, Yamamoto M, Lee WM, Horton JW, Yin HL, Turnage RH: Recombinant plasma gelsolin infusion attenuates burn-induced pulmonary microvascular dysfunction. J Applied Physiol 2004; 96: 25-31.

Smith DB, Jamney PA, Lind SE: Circulating actin-gelsolin complexes following oleic acid-induced lung injury. Am J Pathol 1988; 130: 261-267.

Watt GH, Ashton SH, Cook JA, Wise WC, Halushka PV, Galbraith RM: Alterations in plasma levels and complexing of Gc (vitamin D-binding protein) in rats with endotoxic shock. Circ Shock 1989; 28: 279-291.